Lyophilisation in Pharmaceutical Industry

Lyophilisation in pharmaceutical industry — application

Vacuum freeze drying is also an emerging vocabulary in pharmaceuticals, especially in biopharmaceuticals. Through biopharmaceuticals, many scarce drugs can be produced for hospital use. However, many biotechnology-made drugs must undergo special storage methods, otherwise, the nature of the drugs, etc. will be changed in many aspects, which will affect the efficacy. Therefore, at this time, the vacuum freeze drying came into being. Through this technology, the medicines under the biotechnology can be effectively stored to ensure the service life of the medicines. Biopharmaceuticals have a wide range of medical applications, and they have great requirements for the production environment of medicines and the storage methods as well. Vacuum freeze drying is the most effective way to solve this problem in the biopharmaceutical process.Lyophilisation in Pharmaceutical Industry (2)

Lyophilisation in pharmaceutical industry — process

The lyophilization process in pharmaceutical industry, here we take that in the biopharmaceuticals as an example, is mainly divided into three aspects: pre-freezing, sublimation drying, and decomposing drying.

First of all, in the pre-freezing process, the target is to shape the frozen finished product. During the pre-freezing period, important conditions such as the freezing time and temperature must be mastered so that frozen drugs follow strict freezing conditions to ensure the quality of medicines.

In the sublimation drying stage, the main purpose is to drain the moisture in frozen medicine. This is also the main process of the vacuum freeze drying technology. In this period, the stability required for sublimation is of great importance, and only by keeping the stability can the drying process be accelerated.

In the final process of dissolving and drying, the main purpose is to discharge the residual moisture in the frozen medicine. The drying temperature at this stage should be adjusted according to the performance of the medicine. When the temperature of the biological medicine reaches the pre-requirement, it will be restored again to the vacuum state, and the repeated drying process is carried out. Finally, the biological products under the vacuum freeze drying technology are obtained, so that they can be better preserved.

Lyophilisation in pharmaceutical industry — advantages

The application of lyophilization/lyophilisation in pharmaceutical industry has many advantages. The traditional drying technology will cause the drugs to be damaged and wrinkled, while the vacuum freeze drying technology will leave pores in the dry residue during the sublimation of the solid, which ensures the biological structure of the product not be destroyed. Moreover, the medicines under the vacuum freeze drying technology have no pollution, no extra impurities, and are easy to transport.

Lyophilisation in pharmaceutical industry — notes

There are also some notes that require our attention during the using of lyophilization/lyophilisation in pharmaceutical industry. Firstly, we must pay much attention to the choice of the lyophilization machine since there are many types of dryers. We should find a reliable freeze dryer manufacturer and select the one we need. Secondly, in some countries, the vacuum freeze drying tech is still in its infancy, and its relative technical theory is still immature. Researchers need to further explore and continuously improve the special tech to find more application possibilities.